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Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, quality of life can be improved through palliative procedures.
- The Significance of Ascites in Patients With Pancreatic Ductal ...
Although malignant ascites confers a limited life expectancy...
- The Significance of Ascites in Patients With Pancreatic Ductal ...
The median survival following diagnosis of ascites was 5.7 months. Ovarian cancer favoured longer survival while low serum albumin, low serum protein and liver metastases adversely affected survival. The independent prognostic factors for survival were cancer type, liver metastases and serum albumin.
For most patients, development of malignant ascites signals advanced, incurable cancer. Often, there may be no suitable cure for the underlying cancer. However, for some cancers (eg, ovarian cancer, lymphoma), treating the underlying cancer with chemotherapy and/or surgery may control ascites as well.
12 Σεπ 2023 · Ascites formation is a common complication of cancer with a significant symptomatic burden for patients. Malignant ascites (MA) is defined by the presence of tumor cells within the ascitic fluid. It does not only cause substantial morbidity, but is also associated with impaired survival.
Although malignant ascites confers a limited life expectancy regardless of primary malignancy, 2 prognosis seems worse in patients with gastrointestinal cancers in which mean survival is 10 weeks from the onset of ascites. 3
One of the most common sequela of epithelial ovarian cancer is the occurrence of malignant ascites, which usually portends an advanced stage and worse prognosis [7]. Ascites manifests as continuous abdominal pressure, increased abdominal girth, pain, nausea, bladder/bowel dysfunction, in addition to diminished pulmonary capacity and dyspnea [8].
Drain removal after six hours is recommended. Permanent indwelling peritoneal catheters May help with symptom control by avoiding repeated LVP. PleurX peritoneal catheter is recommended by NICE as an option to manage refractory malignant ascites. The CDG recommend considering after two LVP.
