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Malignant ascites indicates the presence of malignant cells in the peritoneal cavity and is a grave prognostic sign. While survival in this patient population is poor, averaging about 20 wk from time of diagnosis, quality of life can be improved through palliative procedures.
Females survived longer than the males (P = 0.0001) but this is due to better prognosis with ovarian and breast cancer groups. There was improved survival in those patients who had chemotherapy ( P = 0.0001).
Two main reasons cause ascites in patients with cancer. First, cancer can spread to the lining of the organs—the peritoneum—and make it leaky, causing malignant ascites. Second, cancer can spread to the liver and cause increased pressure in the liver.
12 Σεπ 2023 · Especially patients with ovarian cancer show longer survival times as ascites often presents as one of the first symptoms of disease, while patients with pancreatic cancer on the other hand exhibit survival times of less than a month as MA often occurs as an end stage event (submitted).
Women with ascites who received bevacizumab had a median PFS of 15.2 months (95% CI, 14.1–16.2 months) compared to a median of 10.4 months (95% CI, 9.7–11.2 months) for those who did not receive it (p<0.001).
In patients with pancreatic ductal adenocarcinoma (PDAC), ascites is often diagnosed late with average onset of 11 months from the time of diagnosis. Prognosis is poor after ascites development with an estimated median survival of 1.8 months from time of onset.
8 Μαΐ 2020 · Ascites is present in more than one third of ovarian cancer patients at initial diagnosis and in almost all cases of relapse. 3, 8, 9 The greater the volume and frequency with which ascites...
