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21 Αυγ 2014 · Autoimmune neutropenia is frequently a benign disorder that manifests as mild neutropenia, and in the setting of systemic autoimmune disease is a manifestation of the activity of the underlying disorder.
10 Δεκ 2021 · Classically, the degree of neutropenia is subdivided into mild (ANC of 1000-1499/µL), moderate (ANC of 500-999/µL), or severe (ANC <500/µL), with the term “agranulocytosis” reserved for patients with an ANC <200/µL and an absence of neutrophil precursors on bone marrow examination.
6 Σεπ 2024 · Neutropenia refers to a decrease in circulating neutrophils, which for adults corresponds to <1500 cells/microL in most clinical laboratories. This topic discusses the evaluation of the adult patient with unexplained neutropenia.
9 Απρ 2024 · If the ANC falls below 500/microlitre or 0.5 x 10⁹/L, infections may be life-threatening. An ANC of less than 100/microlitre (agranulocytosis) carries a risk of severe, life-threatening infections with susceptibility to opportunistic organism.
27 Απρ 2023 · Five main topics were identified: (1) definition and classification of neutropenias, (2) diagnostic approach, (3) natural history and follow-up, (4) treatment, and (5) special situations, and a number of key questions were formulated for each topic.
Neutropenia is asymptomatic until infection develops. Fever is often the only indication of infection. If neutropenia is severe, typical signs of focal inflammation (erythema, swelling, pain, infiltrates) may be muted or absent. Focal symptoms (eg, oral ulcers) may develop but are often subtle.
8 Δεκ 2012 · It is characterized by mild neutropenia for more than 3 months with an ANC < 1500/μL for white subjects. There is an absence of clinical, serologic, or ultrasound evidence of any underlying disease associated with neutropenia. Often, mild anemia and/or thrombocytopenia may accompany the neutropenia.
