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18 Ιαν 2013 · We found that the conformation of protein-bound ATP is under-represented in ATP in water, which suggests that ATP molecule should be forced to take a specific conformation on a protein to initiate biological functions.
The triphosphate group in ATP can directly alter protein hydration even at very low molar ratios, counteracting the crowding-induced destabilization of human eye-lens γ-crystalline at 1:1 (crystalline:ATP) and enhancing the protein folding of C71G-hPFN1 at 1:2 (C71G:ATP) and hSOD1 at 1:8 (hSOD1:ATP) . In modern cells, ATP not only serves as ...
16 Απρ 2018 · We find that ADP must be exchanged for ATP to drive the rate-limiting remodeling transition that generates the chiral wrap. ATP hydrolysis accelerates subsequent duplex strand passage and is...
Among those, Complex V (also known as the F 1 F 0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria.
ATP structure and function. At the heart of ATP is the nucleotide called adenosine monophosphate (AMP). Like the other nucleotides, AMP is composed of a nitrogenous base (an adenine molecule) bonded to a ribose molecule and a single phosphate group.
3 Ιαν 2019 · Using a network of conformational states, arrested by nucleotide mimics, we herein characterize the reaction coordinates for ATP hydrolysis, DNA loading and DNA translocation using...
In terms of ATP synthesis for the human enzyme, at 0 o, F 1 is proposed to contain ADP and Pi in one site and ATP in a second site, while the third site is empty. The γ-subunit rotates by 30 o, which is followed by the phosphorylation of ADP to ATP.
