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Charging tRNAs requires ATP and proceeds in three steps (shown below). In the first step, ATP and an appropriate amino acid bind to the aminoacyl-tRNA synthase. ATP is hydrolyzed releasing a pyrophosphate (PPi) and leaving an enzyme-AMP-amino acid complex.
3 Σεπ 2024 · This review covers different aspects of translation and metabolism cross-regulation, ranging from how cells receive instructions to reprogram metabolism through translational control to how metabolism and metabolic states influence the protein synthesis machinery and translation control.
5 Δεκ 2023 · Translation is controlled mainly during its initiation, a process which culminates in a ribosome positioned with an initiator tRNA over the start codon and, thus, ready to begin elongation of the...
Translation initiation is the process of assembly of elongation-competent 80S ribosomes, in which the initiation codon is base-paired with the anticodon loop of initiator tRNA (Met-tRNA Meti)...
Cells use ATP to perform work by coupling the exergonic reaction of ATP hydrolysis with endergonic reactions. ATP donates its phosphate group to another molecule via a process known as phosphorylation.
23 Φεβ 2024 · We explore the key mechanisms contributing to the deregulation of protein translation, including functional alterations in translation factors, tRNA, mRNA, and ribosome function.
30 Ιουλ 2022 · ATP functions as the energy currency for cells. It allows the cell to store energy briefly and transport it within the cell to support endergonic chemical reactions. The structure of ATP is that of an RNA nucleotide with three phosphates attached.
