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The autoimmune theory of aging, introduced by Roy L. Walford in 1969, asserts that with age, the immune system tends to lose efficiency and experiences widespread dysfunction, evidenced by autoimmunity (immune reactions against one's own body proteins) and a decreased ability to respond to infection and other immune challenges.
Autoimmune disorders in the elderly have unique clinical presentations, and insidious and atypical symptoms may constitute a challenge for the physician. They are generally milder than in adults and can be controlled by a proper therapeutic treatment.
29 Μαΐ 2019 · It is commonly believed that the incidence of autoimmune diseases, manifesting themselves by rise in disease-specific antibodies on one side and by disease-specific symptoms on the other, is rising with advancing age.
4 Απρ 2013 · The frequent development of autoimmunity in the elderly was suggested to take place in part due to the selection of T cells with increased affinity to self-antigens or to latent viruses. These cells were shown to have a greater ability to be pro-inflammatory, thereby amplifying autoimmunity.
1 Μαΐ 2014 · In this chapter, we will review the age-related changes in the immune response and assess the validity of the immune theory of aging (i.e. that these changes in immune response are the primary...
25 Ιουλ 2015 · PTPN22, a classical shared autoimmunity gene, has been found in patients with many autoimmune disorders, including T1D, RA, SLE, Graves' disease and Crohn's disease. There are several other loci that illustrate the overlap and the predisposition to autoimmunity within families.
3 Μαρ 2012 · Abstract. Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity.
