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The autoimmune theory of aging, introduced by Roy L. Walford in 1969, asserts that with age, the immune system tends to lose efficiency and experiences widespread dysfunction, evidenced by autoimmunity (immune reactions against one's own body proteins) and a decreased ability to respond to infection and other immune challenges.
22 Οκτ 2023 · The autoimmune theory proposes that the immune system is programmed so that it is no longer able to faultlessly distinguish foreign proteins from the body’s own proteins. If this happens the body’s immune system will attack and destroy its own cells.
Antagonistic Pleiotropy (AP) is today the best-accepted theory for the evolutionary origin of aging. According to AP theory, aging is a side effect of genes that are selected for their contribution to fertility and other essential components of individual fitness.
1 Ιαν 2022 · The immunological theory captures many aspects of the aging process, and it may be able to integrate the most widely accepted ones such as the genetic (e.g., replicative senescence of Hayflick, evolutionary theories) (see “Genetic Theories of Aging”; “Antagonistic Pleiotropy Aging Theory”) and stochastic (e.g., free radical) theories ...
1 Μαΐ 2014 · The in vivo manipulation or depletion of Tregs may help devise effective immunotherapy for patients with cancer, autoimmunity, graftversus-host disease, infectious diseases and allergic...
The autoimmune theory proposes that the immune system is programmed so that it is no longer able to faultlessly distinguish foreign proteins from the body's own proteins. If this happens the body's immune system will attack and destroy its own cells.
1 Ιαν 2022 · In this chapter, immunosenescence, autoimmune diseases, fundamental changes of cellular aging, age-related clinical manifestations, and the epidemiology of autoimmune diseases in elderly individuals will be discussed.
