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HIV treatment. AZT was usually dosed twice a day in combination with other antiretroviral therapies. This approach is referred to as Highly Active Antiretroviral Therapy (HAART) and is used to prevent the likelihood of HIV resistance. [12][13] As of 2019, the standard is a three-drug once-daily oral treatment that can include AZT. [14]
AZT: The First Drug to Treat HIV Infection. Scientists funded by NIH’s National Cancer Institute (NCI) first developed azidothymidine (AZT) in 1964 as a potential cancer therapy. AZT proved ineffective against cancer and was shelved, but in the 1980s, it was included in an NCI screening program to identify drugs to treat HIV/AIDS.
18 Σεπ 2024 · In 1987, azidothymidine (AZT) became the first and only FDA-approved drug used to treat HIV/AIDS. AZT helped people live longer, but it couldn’t stop the virus from replicating when taken alone.
19 Μαρ 2017 · The first AIDS drug was approved on March 19, 1987—but getting there was by no means easy. Here's the story behind the treatment.
The discovery of the broad antiretroviral properties of a series of 2′,3′-dideoxynucleosides, the most prominent of which is AZT (3′-azido-2′,3′-dideoxythymidine, zidovudine), showed that treating HIV-1 was possible.
9 Σεπ 2010 · AZT, also called Zidovudine (ZVD) and Retrovir, was the first approved HIV/AIDS drug. It is a reverse transcriptase inhibitor . This type of medicine stops the reproduction of DNA and reduces the amount of the virus in the blood (the viral load).
AZT became the world’s first antiretroviral therapy, targeting one key enzyme in HIV’s cellular takeover strategy. The treatment was developed and marketed by Burroughs Wellcome, which became part of the firm now known as GSK.
