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  1. 14 Απρ 2021 · The continuous introduction of ASs into the aquatic environments is attributed to their resistant behavior to wastewater treatment processes. However, behavior, fate, and long-term ecotoxicological contribution of ASs in water resources is at a large still unknown.

  2. 20 Μαΐ 2024 · The study first constructed an interaction network map of aspartame with gastric cancer targets using network toxicology methods and identified key targets and pathways.

  3. 1 Δεκ 2019 · The qualitative analysis shows that very demanding criteria were used to judge putative positive studies, while far more lax and forgiving criteria were applied to putative negative studies.

  4. 31 Αυγ 2023 · The drinking water exposure produced significant effects (***two-way repeated measures ANOVA, p < 0.0001), suggesting poor performance by the two aspartame groups.

  5. Acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs have consistently found no adverse effect of aspartame with doses up to at least 4000 mg/kg bw/day.

  6. 8 Φεβ 2014 · The gastrointestinal tract hydrolyzes aspartame to aspartyl phenylalanine and methanol. Further hydrolysis of aspartyl phenylalanine to aspartic acid and the essential amino acid, phenylalanine, produces a risk for patients with the homozygous gene for PKU (Rangan and Barceloux 2009).

  7. 1 Δεκ 2022 · Various studies have shown the link between artificial sweeteners and diabetes, i.e., daily intake of (2–15) aspartame tablets (20 mg) administered to 177 persons for 3–15 months revealed no effects of aspartame on blood glucose level, triglycerides and no interaction with the conventional anti-diabetic therapy (Paccalin et al., 1980). In ...