Αποτελέσματα Αναζήτησης
The hydroxamic acid, SH5-07 and the benzoic acid, SH4-54, analogs of BP-1-102 have emerged as potent and selective inhibitors, with single-digit micromolar activities against Stat3 signaling. Studies show that constitutively-active Stat3 in tumors responds variably across tumor lines to small-molecule inhibitors.
While searching for new bioactive compounds, it has been observed that organic molecules with benzoic acid (BA) moiety possess significant anticancer potential. Several works of literature reported the use of BA from natural or synthetic sources to synthesize bioactive chemicals.
29 Μαΐ 2023 · During the process of looking for new chemical entities, it was found that certain compounds with a basic nucleus of benzoic acid (BA) exhibit a remarkable anticancer potential.
29 Ιουλ 2020 · The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus.
1 Φεβ 2016 · STAT3 offers an attractive target for cancer therapy, but small-molecule inhibitors with appealing pharmacologic properties have been elusive. Here, we report hydroxamic acid-based and benzoic acid-based inhibitors (SH5-07 and SH4-54, respectively) with robust bioactivity.
1 Δεκ 2016 · In conclusion, the review summarized: (a) key structural features of phenolic acids required for exhibiting anti-cancer activity; (b) the recently published data highlighting the beneficial effects of biotransformation of phenolic acids by gut microbiota; (c) the mechanisms of action(s) of phenolic acids leading to the inhibition of cancer cell ...
In summary, analysis of in silico docking studies, in vitro and ex vivo studies identified DHBA as a potent HDAC inhibitor compared with benzoic acid or other benzoic acid derivatives. Mechanistically, DHBA induced cancer cell death is mediated by (a) elevated caspase-3 and reactive oxygen species; (b) G2/M phase cell cycle arrest culminating ...
