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Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy.
For the treatment of inflammatory acne, some clinicians prescribe both tretinoin and OTC benzoyl peroxide together but suggest using them at different times of the day. To be on the safe side, use a 3% benzoyl peroxide wash in the morning and tretinoin at night.
A topical retinoid combined with benzoyl peroxide led to IGA improvement compared with vehicle (26.1-34.9% vs 7-11.8%; p < 0.001) at Week 12. Topical retinoid plus an oral antibiotic was superior to vehicle in reducing lesion counts (64-78.9% vs 41-56.8%, p < 0.001).
Benzoyl peroxide and tretinoin are commonly prescribed acne treatments. Historically, they have been difficult to combine in a single formulation due to chemical instability, and both medications are potentially irritating. Microencapsulation helps overcome these challenges.
16 Μαρ 2020 · Topical therapies, including benzoyl peroxide (BPO), tretinoin, antibiotics, and salicylic acid, can be used for non‐inflammatory comedones or mild to moderate inflammatory acne (Strauss 2007; Thiboutot 2009). The underlying mechanism can be action primarily against comedones (retinoids and salicylic acid) or against inflammatory lesions ...
Key Points. For patients with skin of color (SOC), hyperpigmentation due to acne may be more distressing than the acne itself. Rapid effective treatment of acne is an important strategy for improving post-inflammatory hyperpigmentation (PIH) due to acne.
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