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  1. 1 Νοε 2015 · Theories about what causes aging generally fall into one of two groups, genetic or stochastic. Genetic, or programmed theories, propose that aging is genetically determined and organisms have an internal clock that programs longevity.

  2. 20 Ιουλ 2022 · Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how...

  3. Biological clocks act through hormones to control the pace of aging. Recent studies confirm that aging is hormonally regulated and that the evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway plays a key role in the hormonal regulation of aging.

  4. This overview describes the historical background and modern versions of selected theories of the mechanisms of biological aging, including the mutation or genome instability theory, the free radical or oxidative stress theory, the mitochondrial theory, the error...

  5. 24 Μαΐ 2024 · Aging is a complex biological process, which is closely related to cell function [200]. Over the past few decades, a growing body of research has found that cellular senescence is a key driver of many age-related diseases.

  6. 1 Ιαν 2022 · On the other hand, genetically modified shorter telomeres and cell death processes determine the loss of proliferation and regeneration ability. Aging is one of the most complex biological mechanisms called senescence. Theories of aging are usually known as theories of program or damages.

  7. 14 Ιαν 2021 · Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify or drive molecular biological processes underlying each hallmark of aging and contribute to development of age-related diseases such as neurodegeneration and cancer.