Αποτελέσματα Αναζήτησης
1 Νοε 2015 · This theory posits that aging results from glucose binding to proteins, which impairs their biological functions. Protein cross-linking is associated with the connective tissue hardening, cardiac enlargement, and renal disorders.
- Biological Theories of Aging
Cellular senescence has evolved to restrict tumor...
- If You Would Live Long, Choose Your Parents Well
The first question is addressed by the evolutionary theories...
- Thymic Involution With Ageing
Not only does this de- crease in thymus size reduce the...
- Biological Theories of Aging
Biological clocks act through hormones to control the pace of aging. Recent studies confirm that aging is hormonally regulated and that the evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway plays a key role in the hormonal regulation of aging.
22 Αυγ 2020 · Many theories currently trying to explain aging processes and many biomarkers are identified to measure aging and its evolutionary stages. Theories and biomarkers are not studied to extend life span but to guide therapeutic choices and optimize patient management and personalization of care.
This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process.
Aging can be seen as an irreversible, time-dependent, functional decline that converts healthy adults into frail ones, with reduced capacity to adjust to everyday stresses, and increasing vulnerability to most diseases, and to death (1).
1 Νοε 2015 · Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process.
1 Αυγ 2020 · There are many theories of the biological causes of aging, which suggest that many different mechanisms contribute to the aging process. According to Kirkwood, accumulation of random unrepaired molecular damage over time could be the primary cause of cellular aging (Kirkwood, 2005).
