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  1. 1 Νοε 2015 · Theories about what causes aging generally fall into one of two groups, genetic or stochastic. Genetic, or programmed theories, propose that aging is genetically determined and organisms have an internal clock that programs longevity.

  2. Biological clocks act through hormones to control the pace of aging. Recent studies confirm that aging is hormonally regulated and that the evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway plays a key role in the hormonal regulation of aging.

  3. 19 Οκτ 2023 · Different rates of aging could occur in different cells or parts of the body because the telomeres in some cells shorten faster than those in other cells. The heterochromatin loss theory suggests that unwinding of chromosomes happens at many areas in a cell.

  4. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process.

  5. 1 Νοε 2015 · Here, we review known biological theories of aging and how ROS mechanistically control senescence and the aging process. We also describe the redox-regulated signaling networks controlling the SASP and its important role in driving age-related diseases.

  6. 20 Ιουλ 2022 · Drawing on evolutionary theory, network theory and principles of homeostasis, we propose that organismal function is accomplished by the integration of regulatory mechanisms at multiple...

  7. 1 Ιαν 1996 · However, even successful aging is associated with progressive functional impairment and increasing incidence and severity of pathology and disease. The chapter focuses on the major types of cell pathology, cell injury, and cell death. The principal theories of aging are examined in the chapter.

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