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  1. 1 Νοε 2015 · This theory posits that aging results from glucose binding to proteins, which impairs their biological functions. Protein cross-linking is associated with the connective tissue hardening, cardiac enlargement, and renal disorders.

  2. Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.

  3. 22 Αυγ 2020 · Most supporters of the genomic instability theory of aging refer to telomere shortening and mutation in DNA mitochondrial. Telomeres are the repeated DNA sequences at the ends of linear chromosomes, which are unable to be fully replicated by DNA polymerases.

  4. 19 Οκτ 2023 · Theories of aging are difficult to categorize because many of them overlap. As examples, evolutionary theories may incorporate aspects of genetics and behavior; mitochondrial theories may incorporate aspects of free radicals, energy metabolism, membranes, and mitochondrial genetics.

  5. Theories of aging are mixed in that there are different levels of aging phenomena at the molecular, cellular, tissue, organ or systemic levels. George Martin has proposed a classification of the mechanisms of aging into two categories: public and private mechanisms (Martin et al. 1996a).

  6. 24 Μαΐ 2024 · In summary, many studies have linked biological processes such as telomere dynamics, DNA damage response, mitochondrial dysfunction, NAD + loss, autophagy dysregulation, stem cell exhaustion, inflammation, loss of protein balance, dysregulation of nutrient sensing, changes in cell-to-cell communication, and dysbiosis to the triggers behind the ...

  7. 1 Ιαν 2022 · On the other hand, genetically modified shorter telomeres and cell death processes determine the loss of proliferation and regeneration ability. Aging is one of the most complex biological mechanisms called senescence. Theories of aging are usually known as theories of program or damages.

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