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  1. 1 Νοε 2015 · The connection between energy expenditure and longevity may explain why calorie restriction extends lifespans in a diverse group of organisms ranging from single cell yeasts to mammals such as rodents. In some animals, reducing calories by one-third yielded a 40% increase in lifespan.

  2. 20 Ιουλ 2022 · When studied together by microfluidics coupled with time-lapse microscopy, isogenic BY4741 and W303 yeast cells show two different forms of aging: one with decreased ribosomal DNA silencing and...

  3. Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.

  4. 13 Οκτ 2017 · One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.

  5. This overview describes the historical background and modern versions of selected theories of the mechanisms of biological aging, including the mutation or genome instability theory, the free radical or oxidative stress theory, the mitochondrial theory, the error...

  6. 19 Οκτ 2023 · One group of theories, the evolutionary theories, attempts to explain evolutionary aspects of how and why aging exists in living things. Another group, the physiological theories, focuses on how and why aging occurs within present day animals. They explain structural and functional age changes in animal bodies.

  7. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process.

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