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  1. 1 Νοε 2015 · The connection between energy expenditure and longevity may explain why calorie restriction extends lifespans in a diverse group of organisms ranging from single cell yeasts to mammals such as rodents. In some animals, reducing calories by one-third yielded a 40% increase in lifespan.

  2. 20 Ιουλ 2022 · Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how their...

  3. Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.

  4. 10 Αυγ 2024 · Animal models of aging are the focus of this perspective, which discusses how experimental design can be optimized to inform and refine the development of translationally relevant measures and biomarkers of biological age.

  5. This overview describes the historical background and modern versions of selected theories of the mechanisms of biological aging, including the mutation or genome instability theory, the free radical or oxidative stress theory, the mitochondrial theory, the error...

  6. 13 Οκτ 2017 · One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.

  7. 24 Μαΐ 2024 · Aging is a complex biological process, which is closely related to cell function [200]. Over the past few decades, a growing body of research has found that cellular senescence is a key driver of many age-related diseases.