Αποτελέσματα Αναζήτησης
1 Νοε 2015 · Damage theories, sometimes referred to as stochastic theories, propose that chance error and the accumulation of damage over time cause aging. Stochastic theories include wear and tear, error catastrophe, free radical theory, DNA damage hypothesis, loss of adaptive cellular mechanism, and the mitochondrial theory.
- Biological Theories of Aging
The FRTA is one of the most popular aging theories and forms...
- If You Would Live Long, Choose Your Parents Well
Second, identify the set, S, of all individuals with the...
- Thymic Involution With Ageing
These selected cells then migrate to the j.T and A, The...
- Biological Theories of Aging
19 Οκτ 2023 · One way cells seem to keep track of their age is through shortening of their telomeres as they divide. The telomere theory states that shortening of the telomeres alters the expression of other genes, perhaps those closest to the telomeres. This might happen if heterochromatin near the telomere unwinds, allowing detrimental genes to become active.
20 Ιουλ 2022 · When studied together by microfluidics coupled with time-lapse microscopy, isogenic BY4741 and W303 yeast cells show two different forms of aging: one with decreased ribosomal DNA silencing and...
Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.
24 Μαΐ 2024 · Aging is a complex result of many biological processes, and many key factors trigger aging, such as DNA damage, telomere dysregulation, mitochondrial dysregulation, NAD + loss, autophagy disorders, and stem cell exhaustion. Here, we summarise the main causes and underlying molecular mechanisms contributing to the aging process.
This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process.
Here, we discuss the evolutionary aspects of aging and a selection of theories founded on a variety of biological functions that have been shown to be involved in aging in multiple model organisms, ranging from the simple yeast, worms, flies, killifish, and rodents, to non-human primates and humans.
