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  1. 11 Μαρ 2024 · Sliding-window analysis indicated the association between hypertension and brain aging acceleration was moderated by chronological age, showing stronger correlations in midlife but weaker associations in the older age. CONCLUSIONS: Compared with GM, WM was more vulnerable to raised BP.

  2. 31 Μαΐ 2022 · Results: Every 10 mmHg higher DBP was associated with lower brain volumes (GMV: −0.19%–−0.40%) [SE = 47.7–62.4]; WMV: −0.20–−0.23% [SE = 34.66–53.03]; LHCV: −0.40–−0.59% [SE = 0.44–0.57]; RHCV: −0.17–−0.57% [SE = 0.32–0.95]) across all age groups. A similar pattern was detected in both sexes, although it was weaker in men.

  3. Mean years of life (YoL), years of healthy life (YHL) and years of able life (YAL) were calculated over 16 years following the MRI and compared across clusters, using unadjusted and adjusted regression analyses.

  4. 10 Ιαν 2022 · There is a need to develop robust methods to measure small vessel function/pathology, impaired blood-brain barrier, and endothelial dysfunction to test the mechanistic hypothesis by which CVD impacts cognitive aging and dementia.

  5. 11 Αυγ 2005 · The main imaging techniques dedicated to brain hemodynamics are positron emission tomography (PET), single photon emission computed tomography (SPECT), Xenon-enhanced computed tomography (XeCT), dynamic perfusion computed tomography (PCT), MRI dynamic susceptibility contrast (DSC), arterial spin labeling (ASL), and Doppler ultrasound.

  6. 22 Αυγ 2019 · This chapter describes typical structural brain changes seen on imaging studies in “normal” aging and includes practical guidelines for application in daily clinical neuroradiology practice to identify abnormality.

  7. 20 Αυγ 2019 · Primary outcome measures were white matter hyperintensity volume (WMHV) quantified from multimodal MRI using an automated method, amyloid-β positivity or negativity using a standardised uptake value ratio approach, whole-brain and hippocampal volumes quantified from 3D-T1 MRI, and a composite cognitive score—the Preclinical Alzheimer Cognitive C...