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  1. 24 Ιουν 2017 · In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology ...

  2. 9 Φεβ 2017 · The role of serotonin in major depressive disorder (MDD) is the focus of accumulating clinical and preclinical research. The results of these studies reflect the complexity of serotonin signaling through many receptors, in a large number of brain regions, and throughout the lifespan.

  3. 9 Φεβ 2024 · The cerebral cortex, hippocampus, hypothalamus, dorsal raphe (DR) nucleus, arcuate nucleus, and solitary tract nucleus are some regions of the brain that can express leptin receptors.

  4. 21 Μαΐ 2021 · The nicotinic compounds affect different receptors, neurotransmitter systems, and brain areas, with diverse results in individuals experiencing different depressive symptoms or levels of stress . Smoking is associated with depression, which indicates that smoking, namely nicotine intake, may affect the mood [ 303 ].

  5. Increasing evidence supports an important role for the brain’s reward circuitry in controlling mood under normal conditions and contributing importantly to the pathophysiology and symptomatology of a range of mood disorders, such as depression.

  6. 20 Ιουλ 2022 · The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity...

  7. 9 Απρ 2019 · Dysregulation of the brain’s reward circuitry is heavily implicated in the symptomology of depression and the use of genetic and viral tools has enabled us to define the precise cell types that...

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