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23 Δεκ 2011 · BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other. If one copy of either gene is mutated in the germ...
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12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...
7 Νοε 2013 · Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC.
BRCA1 and BRCA2 are large genes in which multiple different types of pathogenic variant have been identified. The majority of these variants are individually rare, and several have only been reported in single families (so-called ‘private’ variants).
BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
1 Σεπ 2004 · In general, the genes that have been identified as being associated with hereditary breast cancer (BRCA1, BRCA2, TP53, CHK2 and ATM) are involved in the maintenance of genomic integrity and DNA...
23 Μαΐ 2024 · The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly distinct functions – homologous recombination, replication fork protection, and single-stranded (ss)DNA gap suppression – and their relative importance is under debate.
