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BRCA1 and BRCA2 are both tumor suppressors whose mutations are the cause of most hereditary breast cancers. Both genes are highly involved in ensuring genome stability. BRCA1 homologs are found in the plant and animal kingdoms while BRCA2 homologs are additionally found in the fungi kingdom.
23 Δεκ 2011 · BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other. If one copy of either gene is mutated in the germ...
12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...
BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated.
1 Ιαν 2009 · BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage.
9 Οκτ 2024 · BRCA1 functions in several crucial cellular pathways that preserve genome stability, including DNA-damage-induced cell-cycle checkpoint activation, DNA-damage repair, chromatin remodeling, transcriptional regulation, and apoptosis, and its mutation is linked to hereditary breast and ovarian cancer syndrome (HBOC). 32 According to the AACR ...
1 Φεβ 2000 · The breast cancer susceptibility genes BRCA1 and BRCA2 encode multifunctional proteins, the mutant phenotypes of which predispose both to breast and to ovarian cancer 1–3. Tumorigenesis in individuals with germline BRCA mutations requires somatic inactivation of the remaining wild-type allele 4.
