Αποτελέσματα Αναζήτησης
19 Ιουν 2011 · One of the most prominent factors involved in HR in mammals is the breast cancer susceptibility gene 1 (BRCA1), which was found while screening for genes involved in familial breast cancer in humans (Hall et al., 1990).
BRCA1 and BRCA2 are both tumor suppressors whose mutations are the cause of most hereditary breast cancers. Both genes are highly involved in ensuring genome stability. BRCA1 homologs are found in the plant and animal kingdoms while BRCA2 homologs are additionally found in the fungi kingdom.
23 Δεκ 2011 · BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other. If one copy of either gene is mutated in the...
BRCA1 and BRCA2 are genes involved in DNA repair. Constitutional (germline) pathogenic variants in these genes are associated with hereditary breast and ovarian cancer, as well as other cancers.
7 Νοε 2013 · Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations.
1 Σεπ 2004 · In general, the genes that have been identified as being associated with hereditary breast cancer (BRCA1, BRCA2, TP53, CHK2 and ATM) are involved in the maintenance of genomic integrity and...
23 Μαΐ 2024 · Two well-described tumour-suppressor genes involved in genome maintenance are BRCA1 and BRCA2. Mutations in the BRCA1 and BRCA2 genes are prevalent in hereditary forms of breast, ovarian, prostate, and pancreatic cancer [2–5], but also occur in about 5% of sporadic tumours [6–9].
