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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
Women with a BRCA1 or BRCA2 (BRCA1/2) inherited gene mutation may be called BRCA1/2 carriers. Most risk factors for breast cancer in women likely impact risk the same way for women who are BRCA1/2 carriers and women who are non-carriers.
6 Ιουν 2024 · BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the most well-known genes linked to breast cancer risk. Everyone has BRCA1 and BRCA2 (BRCA1/2) genes. Some people have an inherited mutation in one or both of these genes that increases the risk of breast cancer.
6 Ιουν 2024 · Women who have a BRCA1 or BRCA2 (BRCA1/2) inherited gene mutation have an increased risk of breast cancer and ovarian cancer. Estimates of these risks vary greatly. Women who have a BRCA1/2 inherited gene mutation have more than a 60% chance of getting breast cancer in their lifetimes and a 10%-60% chance of getting ovarian cancer [2].
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair.
The BRCA1 and BRCA2 genes are two of the most common genes known to be associated with an increased risk of cancer, most notably breast cancer and ovarian cancer. When working properly, BRCA1 and BRCA2 are tumor-suppressor genes that protect the body from developing certain cancers.
According to a recent meta-analysis, BRCA1/2 gene mutations are associated with a 40–57% lifetime risk of female breast cancer and an 18–40% lifetime risk of ovarian cancer [10]. It is also well established that BRCA1/2 carriers with breast cancer have markedly elevated risks of contralateral breast cancer of approximately 50% at 25 years ...
