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Activation of genes by BRCA1 relevant to the cell cycle. BRCA1 has been shown to control the expression levels of four genes—p21WAF1, Gadd45, Cyclin B1, and EGR1—that have implications on checkpoint activation. The p21WAF1 and EGR1 genes
23 Δεκ 2011 · BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous recombination.
BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
1 Ιαν 2009 · BRCA1 and BRCA2 are highly penetrant breast and ovarian cancer susceptibility genes that are mutated in a significant proportion of familial breast and ovarian cancer syndromes. Both of these genes are tumour suppressors, the products of which play vital roles in the cellular response to DNA damage.
9 Οκτ 2024 · BRCA1 functions in several crucial cellular pathways that preserve genome stability, including DNA-damage-induced cell-cycle checkpoint activation, DNA-damage repair, chromatin remodeling, transcriptional regulation, and apoptosis, and its mutation is linked to hereditary breast and ovarian cancer syndrome (HBOC). 32 According to the AACR ...
28 Ιαν 2000 · The breast and ovarian cancer susceptibility gene product BRCA1 has been reported to be expressed in a cell cycle-dependent manner; possess transcriptional activity; associate with several proteins, including the p53 tumor suppressor; and play an integral role in certain types of DNA repair.
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research has shown that BRCA proteins are involved in a multitude of pivotal cellular processes.
