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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
23 Δεκ 2011 · BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other. If one copy of either gene is mutated in the germ...
9 Οκτ 2024 · We established a stable BRCA1 hemizygous cell line (clone 5-9) by deletion of two to three copies of the gene using the CRISPR/Cas9 technology as detailed below.
12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...
17 Ιουν 2022 · BRCA1 is a gene that has many important cellular functions within the body, including DNA repair, cell cycle regulation, and transcriptional regulation of other genes [64,65,66]. Specifically, it binds to complex DNA structures and regulates the G2/M checkpoint protein Chk1 [ 67 , 68 , 69 ].
25 Ιαν 2002 · Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Their ubiquitously expressed protein products are implicated in processes fundamental to all cells, including DNA repair and recombination, checkpoint control of cell cycle, and transcription.
23 Μαΐ 2024 · Two well-described tumour-suppressor genes involved in genome maintenance are BRCA1 and BRCA2. Mutations in the BRCA1 and BRCA2 genes are prevalent in hereditary forms of breast, ovarian, prostate, and pancreatic cancer [2–5], but also occur in about 5% of sporadic tumours [6–9].
