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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous recombination.
Identification of interacting proteins, production of antibodies against the protein, development of knock-out and transgenic mouse models and comparisons between BRCA1 wild-type and mutant-expressing cells has assisted in placing functional characteristics with the BRCA1 protein.
9 Οκτ 2024 · BRCA1 functions in several crucial cellular pathways that preserve genome stability, including DNA-damage-induced cell-cycle checkpoint activation, DNA-damage repair, chromatin remodeling, transcriptional regulation, and apoptosis, and its mutation is linked to hereditary breast and ovarian cancer syndrome (HBOC). 32 According to the AACR ...
23 Μαΐ 2024 · Two well-described tumour-suppressor genes involved in genome maintenance are BRCA1 and BRCA2. Mutations in the BRCA1 and BRCA2 genes are prevalent in hereditary forms of breast, ovarian, prostate, and pancreatic cancer [2–5], but also occur in about 5% of sporadic tumours [6–9].
25 Ιαν 2002 · Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers. Their ubiquitously expressed protein products are implicated in processes fundamental to all cells, including DNA repair and recombination, checkpoint control of cell cycle, and transcription.
6 Αυγ 2024 · Mutations in BRCA1 and BRCA2 genes can occur at any location within the gene structure. These genes have been found to possess a range of mutations that can increase vulnerability to BC and OC to varying extents.
