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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
23 Μαΐ 2024 · The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly distinct functions – homologous recombination, replication fork protection, and single-stranded (ss)DNA gap suppression – and their relative importance is under debate.
BRCA1 is a pleiotropic DDR protein that functions in both checkpoint activation and DNA repair, whereas BRCA2 is a mediator of the core mechanism of homologous recombination.
12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...
1 Σεπ 2004 · In general, the genes that have been identified as being associated with hereditary breast cancer (BRCA1, BRCA2, TP53, CHK2 and ATM) are involved in the maintenance of genomic integrity and DNA...
6 Αυγ 2024 · Mutations in BRCA1 and BRCA2 genes can occur at any location within the gene structure. These genes have been found to possess a range of mutations that can increase vulnerability to BC and OC to varying extents.
1 Φεβ 2000 · The breast cancer susceptibility genes BRCA1 and BRCA2 encode multifunctional proteins, the mutant phenotypes of which predispose both to breast and to ovarian cancer 1–3. Tumorigenesis in individuals with germline BRCA mutations requires somatic inactivation of the remaining wild-type allele 4.
