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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
23 Ιουλ 2023 · Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer.
The greatest risk factor for breast and ovarian cancer is inheritance of a mutation in one of the breast cancer susceptibility genes, BRCA1 or BRCA2. BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other.
4 Σεπ 1998 · BRCA1- and BRCA2- associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a B...
Family planning implications. Key messages. Resources. Gene function. BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 1 (BRCA2) are tumour suppressor genes with a central role in the homologous recombination repair (HRR) pathway. HRR is the major pathway for the repair of double-stranded DNA breaks.
1 Σεπ 2004 · The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer,...
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
