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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
The greatest risk factor for breast and ovarian cancer is inheritance of a mutation in one of the breast cancer susceptibility genes, BRCA1 or BRCA2. BRCA1 and BRCA2 are tumour suppressor genes, the coding regions of which show no homology to previously described proteins or to each other.
7 Νοε 2013 · BRCA1 and BRCA2 gene mutations in Eastern Europe. Open in a separate window. Table 5.
BRCA1 and BRCA2 are genes involved in DNA repair. Constitutional (germline) pathogenic variants in these genes are associated with hereditary breast and ovarian cancer, as well as other cancers.
1 Σεπ 2004 · The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer,...
21 Ιουν 2022 · The breast cancer susceptibility gene 1 (BRCA1) and 2 (BRCA2) are tumour suppressor genes required in pathways responsible for repairing damaged DNA, transcriptional regulation, and...
6 Οκτ 2017 · A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes.
