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BRCA1 (BReast CAncer gene 1) and BRCA2 (BReast CAncer gene 2) are genes that produce proteins that help repair damaged DNA. Everyone has two copies of each of these genes—one copy inherited from each parent.
- Genetic Testing Fact Sheet
Genetic testing can give several possible results: positive,...
- Risk Factors
The list below includes the most-studied known or suspected...
- Genetic Testing Fact Sheet
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair.
23 Ιουλ 2023 · Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer.
1 Σεπ 2004 · The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and...
17 Ιουν 2022 · We review the molecular regulation of the expression of the protooncogenes in breast cancer and their interrelationships with iNOS expression and activities. In addition, we discuss the roles of iNOS, HER2, BRCA1/2, and NO metabolism in the pathophysiology of cancer stem cells.
6 Αυγ 2024 · Mutations in BRCA1 and BRCA2 genes can occur at any location within the gene structure. These genes have been found to possess a range of mutations that can increase vulnerability to BC and OC to varying extents.
About This PDQ Summary. Genetics. In This Section. Prevalence of BRCA1/2 Pathogenic Variants. BRCA1/2 founder pathogenic variants. BRCA1/2 de novo pathogenic variant rate. Detection of BRCA1/2 Variants. Indications for BRCA1/2 Genetic Testing. Related Conditions.
