Αποτελέσματα Αναζήτησης
7 Νοε 2013 · BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations.
- Low Frequency of Brca1 Germline Mutations in 45 German Breast/Ovarian Cancer Families
The missense mutation was also found in 2.8% of the general...
- Penetrances of Brca1 1675delA and 1135insA With Respect to Breast Cancer and Ovarian Cancer
We have previously reported two BRCA1 founder mutations in...
- Evidence Against Palb2 Involvement in Icelandic Breast Cancer Susceptibility
A dominant pattern of inheritance is evident in...
- Brca1 and Brca2 Germline Mutation Analysis in The Indonesian Population
Introduction. Breast cancer is the most common cancer in...
- Li-Fraumeni-like Syndrome Associated With a Large Brca1 Intragenic Deletion
In the MLPA analysis none of the patients showed TP53, or...
- PMC Free Article
Background. A large number of distinct mutations in the...
- Low Frequency of Brca1 Germline Mutations in 45 German Breast/Ovarian Cancer Families
12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...
The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair.
23 Ιουλ 2023 · Breast cancer genes BRCA1 and BRCA2 are tumor suppressor genes whose mutations significantly increase the likelihood of developing particular types of epithelial malignancies, namely breast and ovarian cancer.
3 Μαρ 2023 · Germline pathogenic variants in BRCA1/BRCA2 are associated with ovarian cancer, fallopian tube cancer, primary peritoneal cancer, male breast cancer, prostate cancer, pancreatic cancer, and early-onset breast cancer. BRCA1/BRCA2 -associated cancer risks are inherited in an autosomal dominant manner.
21 Ιουν 2022 · BRCA1 and BRCA2 are tumour suppressor genes that play a critical role in maintaining genomic stability via the DNA repair mechanism. DNA repair defects caused by BRCA1 and BRCA2 missense...
BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 1 (BRCA2) are tumour suppressor genes with a central role in the homologous recombination repair (HRR) pathway. HRR is the major pathway for the repair of double-stranded DNA breaks.
