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1. www.cancer.gov › about-cancer › causes-preventionBRCA Gene Changes: Cancer Risk and Genetic Testing

   www.cancer.gov › about-cancer › causes-prevention

   • Αποθηκευμένο αντίγραφο

   Testing for inherited changes in BRCA1 and BRCA2 can give several possible results: a positive result (a harmful change in the gene is present), a negative result (no harmful gene change is present), or a gene change (variant) of uncertain significance (VUS) result.

   • Genetic Testing Fact Sheet

     Genetic testing can give several possible results: positive,...

   • Risk Factors

     Aspects of a person's age, family history, lifestyle, and...

2. pmc.ncbi.nlm.nih.gov › articles › PMC6979404Differentially expressed genes and key molecules of...

   pmc.ncbi.nlm.nih.gov › articles › PMC6979404

   BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated. This study aims to identify the gene ...

3. pmc.ncbi.nlm.nih.gov › articles › PMC4972490BRCA1 and BRCA2: different roles in a common pathway of genome...

   pmc.ncbi.nlm.nih.gov › articles › PMC4972490

   The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and BRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair.

4. www.cell.com › molecular-cell › fulltextBRCA1 levels and DNA-damage response are controlled by the...

   www.cell.com › molecular-cell › fulltext

   9 Οκτ 2024 · BRCA1 functions in several crucial cellular pathways that preserve genome stability, including DNA-damage-induced cell-cycle checkpoint activation, DNA-damage repair, chromatin remodeling, transcriptional regulation, and apoptosis, and its mutation is linked to hereditary breast and ovarian cancer syndrome (HBOC). 32 According to the AACR ...

5. www.nature.com › articles › ejhg201693The biological effects and clinical implications of

   www.nature.com › articles › ejhg201693

   12 Αυγ 2016 · BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or...

6. www.ncbi.nlm.nih.gov › pmc › articlesMolecular contribution of BRCA1 and BRCA2 to genome instability...

   www.ncbi.nlm.nih.gov › pmc › articles

   1 Οκτ 2020 · BRCA1 and BRCA2 are two highly penetrant genes involved in the inherited breast cancer and contribute to different DNA damage pathways and cell cycle and apoptosis cascades. Mutations in these genes have been associated with hypersensitivity and genetic instability as well as manifesting severe radiotherapy complications in breast cancer patients.

7. pmc.ncbi.nlm.nih.gov › articles › PMC6765401How do mutations affecting the breast cancer genes BRCA1 and...

   pmc.ncbi.nlm.nih.gov › articles › PMC6765401

   Germline mutations affecting a single copy of the breast cancer genes BRCA1 or BRCA2 significantly increase the risk of breast and ovarian cancer (reviewed in Nathanson et al., 2001; Rahman and Stratton, 1998; Welcsh and King, 2001).