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The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain.
Roughly 10%–20% of ovarian cancer patients have a first-degree relative with either breast cancer, ovarian cancer, or both [4]. Two highly penetrant genes that confer greatly increased risk of both breast and ovarian cancer have thus far been identified; BRCA1 and BRCA2 which confer a 40% and 15% lifetime risk of ovarian cancer, respectively [5–9].
12 Σεπ 2023 · We have refined age-specific breast and ovarian cancer risks for BRCA1 and BRCA2 carriers of Chinese ancestry and quantified for the first time the cancer risks for carriers of Malay and Indian ancestry. Our findings show that the cancer relative risks in Asian carriers, vary by age, highlighting the importance of using age-specific relative ...
Germline mutations of the BRCA1 and BRCA2 genes confer a high life‐time risk of ovarian cancer. They represent the most significant and well characterised genetic risk factors so far identified for the disease.
4 Σεπ 1998 · BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer, ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a ...
25 Ιαν 2022 · We used data from 3,184 BRCA1 and 2,157 BRCA2 families in the Consortium of Investigators of Modifiers of BRCA1/2 to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment.
This review focuses on common genetic polymorphisms that modify the risk of breast and ovarian cancer in female BRCA1 and BRCA2 mutation carriers, based on the current evidence, and on their implications for cancer risk prediction in these women.
