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On completion of this article, you should be able to (1) recognize patients at risk for vitamin D deficiency, (2) optimally use and interpret serum vitamin D testing, and (3) determine the optimal vitamin D therapy required to treat or prevent vitamin D deficiency in adults.
12 Αυγ 2024 · Various studies have estimated that it takes up to 24 hours for vitamin D3 supplements to raise vitamin D levels in the bloodstream. However, vitamin D then needs to be converted to its active form (calcitriol, also called 1,25-dihydroxycholecalciferol or 25(OH)D).
17 Ιουλ 2023 · Systemically, calcitriol binds to vitamin-D receptors in the kidneys, parathyroid glands, intestines, and bones to increase serum blood calcium levels by promoting absorption in the intestines, renal tubular reabsorption in the kidneys, and release from bone.
D and appears to be two to three times more effective in increasing serum 25OH-D levels than vitamin D3 , and this feature of calcidiol might be very important also in early stages of the COVID-19 disease, when low serum 25OH-D levels need to be increased as soon as possible [8,61].
16 Μαΐ 2023 · Vitamin D has a variety of actions on calcium, phosphate, and bone metabolism. Its most important biological action is to promote enterocyte differentiation and the intestinal absorption of calcium and phosphorus, thereby promoting bone mineralization.
Regardless of the pattern of administration, cholecalciferol may be more likely to achieve serum levels of 25 (OH)D (25-hydroxy-vitamin D) of 30–50 ng/mL, an interval considered optimal for maximum benefit at the lowest risk.
Even at full vitamin D repletion [i.e., 25(OH)D levels ≥80 nmol/L), absorption fraction may be higher or lower than the plateau level shown in Figure 3, depending solely on calcitriol production, which reflects calcium need. (Calcitriol, in turn, is regulated by parathyroid hormone, itself reacting to perceived calcium need.)
