Αποτελέσματα Αναζήτησης
More recently, other modes of cell death, notably anoikis and autophagic cell death, have been demonstrated to also be modulated by Ca(2+) transients. Characteristics, interrelationship and mechanisms involved in Ca(2+) regulation of these cell death modalities are discussed in this review.
1 Μαρ 2018 · Ca 2+ regulates cell cycle proliferation and cell death mainly through the Ca 2+ /calmodulin complex. Ca 2+ participates in the control of the cell cycle through three checkpoints. Alterations in all these processes may lead to cell cycle arrest and apoptosis.
1 Σεπ 2011 · Presence of calcium in various intracellular compartments leads to activation of different molecules, involved in regulation of cell death. Modulation/disruption of Ca 2+ signaling might result in the activation of multiple cytotoxic mechanisms, including mitochondrial permeability transition and disruption of cytoskeletal organization.
Recent results have underscored the role of calcium in ischemic cell death. A coupling has been demonstrated among glutamate release, calcium influx, and enhanced production of reactive metabolites such as ·O 2−, ·OH, and nitric oxide.
28 Σεπ 1981 · Studies in intact animals and in cell culture suggest than an ultimate influx of calcium ions across injured plasma membranes and along a steep concentrations gradient converts potentially reversible alterations into the irreversible injury of cell death.
15 Οκτ 1998 · One of the paradoxes surrounding Ca 2+ is that it is a signal for both life and death — although elevations in Ca 2+ are necessary for it to act as a signal, prolonged increases in the...
Loss of Ca 2+ homeostasis, often in the form of cytoplasmic increases, leads to cell injury. Depending upon cell type and the intensity of Ca 2+ toxicity, the ensuing pathology can be reversible or irreversible.
