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11 Οκτ 2016 · Recent randomized data suggest that calcium supplements may be associated with increased risk of cardiovascular disease (CVD) events. Using a longitudinal cohort study, we assessed the association between calcium intake, from both foods and supplements, and atherosclerosis, as measured by coronary artery calcification (CAC). Methods and Results.
A group of academic and industry experts in the fields of nutrition, cardiology, epidemiology, food science, bone health, and integrative medicine examined the data on the relationship between calcium supplement use and risk of cardiovascular events, with an emphasis on 4 of the Bradford Hill criteria for causal inference: strength, consistency,...
18 Ιουν 2022 · Calcium supplementation has been advocated for treating and preventing osteoporosis [6]. However, studies have reported negative cardiovascular effects of calcium supplement intake and stated that calcium intake might be related to an increased risk of myocardial infarction [7] and ischemic stroke [8].
1 Ιουλ 2015 · This study randomized 36 282 women to daily intake of 1000 mg calcium carbonate with 400 IU vitamin D versus placebo. 10 No significant differences were found between CaD supplementation compared with placebo for mean systolic or diastolic blood pressure change over time.
Flow diagram outlining the search strategy used to identify new publications that report randomized controlled trial (RCT) data on vitamin D, calcium, vitamin C, multivitamins, antioxidants, B-complex, folic acid, and niacin supplementation and risk of cardiovascular disease and all-cause mortality.
Evidence from meta-analyses. Given the heterogeneity in the results of studies of calcium supplementation, Bolland et al. [] in 2010 published a meta-analysis of the effect of calcium supplementation on cardiovascular outcomes.The trial-level analysis showed that calcium supplementation was associated with a higher risk of MI (RR, 1.27; 95% CI, 1.01 to 1.59), but not with stroke, composite ...
1 Φεβ 2021 · Substantial epidemiological observational science has consistently and independently linked low blood concentrations of vitamin D, as measured by serum 25-hydroxyvitamin D (25 [OH]D), to elevated cardiovascular disease (CVD) risk (4–12).
