Αποτελέσματα Αναζήτησης
28 Απρ 2020 · Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms.
1 Σεπ 2020 · There is one characteristic of cancer that is not shared with normal tissues: the inversion of the pH gradient, where intracellular pH (pHi) becomes alkaline and extracellular pH (pHe) becomes...
3 Μαρ 2014 · In summary, the plasticity of pH i regulation and versatility of protein pH sensitivity offer a mechanism for cancer cells to exploit pH as a selection pressure. By contrast, the genetic stability of normal host cells would hinder their adaptability to the micro-environment.
29 Αυγ 2022 · Cancer cells have an inverted pH gradient: extracellular and intracellular pHs (pHe, pHi) are acid and alkaline, respectively (1). The acid shift in the tumor microenvironment (TME) is closely associated with hypoxia (2) but, more specifically, with highly activated glycolysis in tumor cells.
19 Οκτ 2023 · The role of pH in cancer biology, including its impact on cellular repair, tumor markers, tumor stages, isoenzymes, and therapies, is highlighted. pH variations can affect cellular repair...
11 Αυγ 2011 · Dysregulated pH is emerging as a hallmark of cancer because cancers show a 'reversed' pH gradient with a constitutively increased intracellular pH that is higher than the extracellular...
