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Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CB 1 R and leading to increased caloric intake, reduced metabolic rates, and weight gain.
The way that cannabis may affect weight loss is through the cannabinoid THCV. In low to moderate doses, THCV may block CB1 receptors in the brain that control appetite. But in higher doses, THCV is psychoactive and could have some of the same effects as THC, including appetite stimulation.
5 Αυγ 2020 · The anorexia/cachexia syndrome is the result of weight loss (caused by changes in taste, lack of hunger) and increased energy metabolism; cannabis use has been associated with an increase in appetite and weight gain, leading to examination of its therapeutic effect on cancer and HIV-associated anorexia/cachexia.
13 Ιαν 2020 · Aim: This narrative literature review aims to provide a brief introduction for the geriatrician to the potential indications, evidence-base, contra-indications and side effects of medical cannabinoids in older people. Methods: A search was conducted of CENTRAL, Medline, Embase, CINAHL and psycINFO, Cochrane and Web of Science databases.
10 Σεπ 2018 · The conversion of white in beige adipose tissue is a potential new therapeutic target for obesity. Cannabinoid receptors (CB) regulate thermogenesis, food intake and inflammation. CB1 ablation or inhibition helps reducing body weight and food intake.
Conclusion: It is concluded that phytocannabinoids derived from Cannabis sativa have therapeutic potential due to its anti-inflammatory, antioxidant, and neuroprotective properties, making the plant a study option to reduce and reverse inflammation and comorbidities associated with obesity.
6 Απρ 2020 · Cannabis use among older adults has been steadily increasing, due to lessening stigma and increased interest in using medical marijuana. But there are specific concerns for older people, so anyone considering this option should have a conversation with their doctor weighing the benefits and risks.