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Blood urea nitrogen (BUN): Elevated BUN levels indicate impaired kidney function. Serum creatinine: Increased creatinine levels suggest reduced kidney function. Symmetric dimethylarginine (SDMA): SDMA is a more sensitive and specific marker for kidney disease compared to traditional markers like BUN and creatinine.
Glomerular filtration rate (GFR) is the gold standard measurement of renal function; however, its measurement is rarely indicated in patients with CKD. Creatinine and, to a lesser extent, BUN are correlated with GFR, but, as noted earlier, GFR must be reduced by 75% before azotemia is seen.
29 Ιουν 2023 · Acute or chronic kidney disease in dogs is a serious and progressive health concern. Early detection and proper management can extend your dog's life.
3 Ιαν 2024 · High levels of BUN (blood urea nitrogen) and creatinine in dogs can indicate a problem with their kidneys. Luckily, there are steps you can take to help lower these levels and support your dog’s kidney health.
A dog in compensated chronic kidney failure with marginal kidney function may have normal levels of BUN and creatinine but will have a low urine specific gravity. If a major stress such as illness or surgery occurs, the kidneys may fail, sending the blood test values up quickly.
Increased BUN is most often associated with significant hypovolemia, renal disease, or urinary obstruction and can be found in conjunction with other markers of decreased glomerular filtration (eg, increased creatinine). Clinical signs are associated with underlying pathology.
A dog can lose up to 75% of kidney function before showing any changes in renal blood values such as elevated BUN and creatinine levels. Therefore, these traditional diagnostic methods could detect kidney failure only after a significant loss of function, making early intervention difficult.
