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CDP Choline, its half life, and finding the correct dosage. Discussion. I'm tying myself up in knots trying to start supplementing choline. A week or two ago, there was a post in r/Nootropics which linked Alpha-GPC usage to long-term increased risk of stroke.
Experience with CDP-Choline? I had tried the C4 "Smart" energy drink and kind of enjoyed it. I looked up the ingredient they were focusing on, CDP Choline, and did some research. Ended up ordering the powder by itself. This is what I got.
Raising choline level primarily in brain vs body - CDP-Choline provides the uridine needed for phosphatidylcholine synthesis. CDPC passes brain barrier due to its cytidine/uridine. Brain consumes 20-25% of energy from what body consumes. So imo cdp- choline would make it to brain.
Following as I started cdp choline 2 weeks ago taking 500mg split during the day (along with 30 mg Noopept and 30mg Vyvanse). I took a break from it Sunday and had a bad headache, body aches, and brain fog on Monday. Not sure if it’s related either but sounded similar to what you described.
I know this is an old post, but I've been having caffeine (a cup or two), 250 mg of CDP-choline, about 100 mg of L-Theanine, and algae-based omega-3 DHA and EPA. For me, it amplifies the effect of the L-Theanine and coffee in a controllable way.
most of the studies that I looked at for CDP choline indicate recovery from stroke or to prevent cognitive decline in older people these dosages are 500mg +. IMO you shouldn't need to take that high of a dose as the studies indicated for attention done in healthy people noted that 250mg was better than 500 mg:
The lone study stating this figure noticed bi-phasic spikes in plasma choline (not cdp-choline) post intake: the much larger of the two at two hours, the smaller, plateued peak at 24 hours. Looks like that second peak of choline was used to determine the 60hr hl of the parent compound cdp-choline.
