Αποτελέσματα Αναζήτησης
10 Μαρ 2020 · In recent years, in the effort to clarify the risk of developing dementia or AD, increasing attention has been devoted to the differences between men and women in the causes and manifestations of...
Recent successes of genetic therapies in other neurodegenerative diseases may highlight the way forward. This scoping review explores suggested targets of genetic therapy in AD, with a focus on vector-based approaches in pre-clinical and clinical trials.
20 Ιουν 2024 · Available therapeutic strategies for Alzheimer's disease (AD) rely on behavioral management (e.g. healthy diet and physical activity, music and light therapy), care and support of patients, medications, cell-based therapy, and gene therapy.
24 Απρ 2018 · We outline strategies to implement genomics into translational clinical research that will not only improve accuracy of dementia diagnosis, thus enabling more personalized treatment strategies, but may also speed up the discovery of novel drugs and interventions.
Treating a broad AD population with gene therapy has been difficult owing to the multifactorial nature of the disease, with limited genetic targets available. Here we tested whether targeting murine CD33 using a vector-delivered artificial microRNA (amiR) specific for CD33 (miR CD33 ) could reduce amyloid burden in APP/PS1 mice.
23 Σεπ 2021 · Putative targets of genetic therapies tested in pre-clinical trials include amyloid pathway intermediates and enzymes modulation, tau protein downregulation, APOE4 downregulation and APOE2 upregulation, neurotrophin expression (nerve growth factor (NGF) and brain-derived neurotrophic factor), and inflammatory cytokine alteration, among several ...
that women are at a higher risk than men for developing dementia or Alzheimer’s disease (AD); however, the reasons for these differences are not completely known, and the debate is still...
