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3 Ιουλ 2023 · This activity outlines the indications, action, and contraindications for Chloramphenicol as a valuable agent in the treatment of superficial eye infections, otitis externa, Typhoid fever, and other severe life-threatening conditions, especially those caused by Haemophilus influenza.
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Chloramphenicol should not be used topically because small amounts may be absorbed and, rarely, cause aplastic anemia. Hypersensitivity reactions are uncommon. Optic and peripheral neuritis may occur with prolonged use.
Reasonable precautions taken to prevent excessive exposure to light or moisture are adequate to prevent significant decomposition over an extended period. In solution, chloramphenicol undergoes a number of degradative changes related to pH, temperature, photolysis and microbiological effects.
14 Ιουν 2024 · Meningitis. Alternative for treatment of meningitis caused by susceptible bacteria, including Haemophilus influenzae, Neisseria meningitidis, or Streptococcus pneumoniae. Generally used only when penicillins and cephalosporins are contraindicated or ineffective.
Contraindications. Hypersensitivity to chloramphenicol or any component of the formulation; treatment of trivial or viral infections; bacterial prophylaxis. Dosage and Administration Dosing: Adult. Serious infections: IV: 50 to 100 mg/kg/day in divided doses every 6 hours; maximum daily dose: 4 g/day (Moffa 2015). Dosing: Geriatric. Refer to ...
1 Φεβ 2024 · Pediatric. Newborn infants are especially sensitive to the side effects of chloramphenicol because they cannot remove the medicine from their body as well as older children and adults.
