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10 Μαρ 2015 · Individuals with ACTA2 mutations present with both type A and type B aortic dissections at significantly younger ages than individuals enrolled in the International Registry of Acute Aortic Dissection (IRAD) study 22 and are likely to report a family history of thoracic aortic disease.
- Acta2
ACTA2 (actin, -2, smooth muscle, aorta; OMIM *102620) α is...
- Circulation
Background— TGFBR2 mutations were recognized recently among...
- Acta2
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction.
1 Οκτ 2024 · ACTA2 (Actin Alpha 2, Smooth Muscle) is a Protein Coding gene. Diseases associated with ACTA2 include Smooth Muscle Dysfunction Syndrome and Aortic Aneurysm, Familial Thoracic 6. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase ...
29 Οκτ 2013 · Here, we have used in vitro and in vivo wound healing models to explore the functional role of Acta2 in this transformation. Acta2 was abundant in activated cells isolated from injured livers but was undetectable in quiescent cells isolated from normal livers.
1 Ιουν 2021 · Work by Milewicz et al [52]. showed that ACTA2 proliferative and secretory activities as well as transition from a contractile to a synthetic phenotype was the underlying mechanism of vasculogenesis [41], [52]. Furthermore, explanted smooth muscle cells and myofibroblasts from patients with mutations in ACTA2 revealed that the increased ...
There are many possible mechanisms by which the ACTC1 protein promotes oncogenesis. One possibility could be through annexins which are Ca 2+-dependant, phospholipid-binding proteins that function in vesicle trafficking, cell proliferation and apoptosis. Annexin expression is correlated with shorter survival, tumorigenesis, and the progression ...
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell mo tility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis.
