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Mechanism of action. Clopidogrel is activated via a 2 steps reaction to an active thiol-containing metabolite. 3 This active form is a platelet inhibitor that irreversibly binds to P2Y 12 ADP receptors on platelets. 9 This binding prevents ADP binding to P2Y 12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet ...
Clopidogrel is a pro-drug that is metabolised by the cytochrome P450 system to generate the active metabolite which irreversibly inhibits the adenosine diphosphate (ADP) P2Y 12 receptor.
10 Ιουλ 2023 · Mechanism of Action. Clopidogrel is an irreversible inhibitor of the platelet P2Y12 adenosine diphosphate receptor. Inhibition of this receptor prevents the downstream activation of the glycoprotein IIb/IIIa receptor complex, which leads to reduced platelet aggregation.
Download scientific diagram | Activation and mechanism of action of clopidogrel. Orally administered clopidogrel is absorbed in the intestine. The efflux pump P-glycoprotein (P-gp)...
The full mechanism of action of clopidogrel can be seen in Figure 2. Clopidogrel is a pro-drug that is metabolized by the cytochrome P450 system to generate the active metabolite which ...
The antiaggregating properties of this compound are well known and, very recently, new results have clarified its mechanism of action. Clopidogrel is active only after intravenous or oral administration, and no circulating activity has been found in the plasma of treated animals or human volunteers.
17 Φεβ 2020 · Mechanism of Action. Clopidogrel requires in vivo biotransformation to an active thiol metabolite. The active metabolite irreversibly blocks the P2Y 12 component of ADP receptors on the platelet surface, which prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet aggregation.
