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  1. One of the hallmarks of S. aureus is its ability to coagulate blood , allowing for clinical differentiation of S. aureus from coagulase-negative Staphylococci (CoNS) such as S. epidermidis . S. aureus secretes two soluble coagulases that interact with prothrombin to catalyze conversion of fibrinogen to fibrin ( McAdow et al., 2012b ).

  2. 5 Αυγ 2010 · The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules.

  3. Clinical isolates of Staphylococcus aureus secrete coagulases, polypeptides that bind to and activate prothrombin, thereby converting fibrinogen to fibrin and promoting the clotting of plasma or blood.

  4. 5 Ιουλ 2024 · The coagulase enzyme, produced by Staphylococcus aureus, is a protein that plays a significant role in the bacterium’s interaction with its host. This enzyme exists in two forms: bound coagulase, also known as “clumping factor,” and free coagulase.

  5. 1 Ιαν 2018 · Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections

  6. 5 Αυγ 2010 · Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.

  7. 1 Ιαν 2016 · One of the hallmarks of S. aureus is its ability to coagulate blood (Loeb, 1903), allowing for clinical differentiation of S. aureus from coagulase-negative Staphylococci (CoNS) such as Staphylococcus epidermidis (Lowy, 1998).

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