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Structure. Tissue factor belongs to the cytokine receptor protein superfamily and consists of three domains: [11] an extracellular domain, which consists of two fibronectin type III modules whose hydrophobic cores merge in the domain-domain interface. This serves as a (probably rigid) template for factor VIIa binding. a transmembrane domain.
23 Ιαν 2021 · The factor XII-driven-contact system starts coagulation and inflammatory mechanisms via the intrinsic pathway of coagulation and the bradykinin-producing kallikrein-kinin system, respectively.
6 Ιουν 2023 · TF (also known as thromboplastin, coagulation factor III, F3 or (CD142) is a transmembrane glycoprotein receptor for coagulation factors VIIa and X with a molecular weight of 47 kDa is located on the different cells. TF can initiate blood coagulation upon binding to FVIIa [4, 20, 28,29,30].
Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works on an insoluble substrate; 3) its potentially active subunit is also present in the cytoplasm of platelets, monocytes, monocyte-derived macrophages, dendritic cells ...
The coagulation factors work together in a cascade pathway where one factor, when activated, activates the next factor in the sequence. The purpose is to generate the key thrombin enzyme and produce fibrin (a localized thrombus). The sequence of coagulation factor activation is shown in Figure 35.4.
19 Ιουλ 2015 · This interactive database incorporates all five factors factor II, factor VII, factor IX, factor X and protein C and their corresponding mutational information. The mutations were correlated with experimentally quantifiable phenotypes with the help of data available on consensus domain structures.
1 Ιαν 2020 · Coagulation is the process by which flowing liquid blood plasma is converted to a soft, viscous gel entrapping the cellular components of blood including red cells and platelets and thereby preventing extravasation of blood. This process is triggered by the minimal proteolysis of plasma fibrinogen.
