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This review aims to discuss the role of dietary sugar in NAFLD pathogenesis, the health and economic burden, and the promising potential of sugar reduction to improve health outcomes for patients with this chronic liver disease.
It is now generally thought that increased consumption of added sugar, in particular fructose sweeteners, 3–6 is one of the major underlying causes of chronic metabolic diseases, including obesity, insulin resistance, non-alcoholic fatty liver disease (NAFLD), diabetes, and cardiovascular diseases. 7– 12 In this review, we will focus on the effe...
If we eat sugar on a regular basis, the chemicals build up in our bodies affecting our liver and some other internal organs, which can eventually lead to liver damage. When the liver is damaged, fatty or inflamed, it can’t work as efficiently as a healthy liver.
If sugar is consumed on a regular basis, it can cause chronic and systemic inflammation throughout the body. The liver is just one of the organs affected by this inflammation, and it can lead to liver damage or enlargement. Sugar has also been shown to directly suppress the immune system.
The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes.
10 Δεκ 2021 · Both hyperglycemia and excessive sugar intake disrupt the intestinal barrier, thus increasing gut permeability and causing profound gut microbiota dysbiosis, which results in a disturbance in mucosal immunity that enhances infection susceptibility.
20 Ιαν 2022 · Background. Although the role of a diet rich in fructose and saccharose in development of nonalcoholic fatty liver disease (NAFLD) is well known, the effects of a low free sugar diet in the...
