Αποτελέσματα Αναζήτησης
23 Απρ 2024 · Here, we identify three categories of axis-associated genomic sites: PRDM9 binding sites, where DSBs form; binding sites of the insulator protein CTCF; and H3K4me3-enriched sites. We demonstrate that PRDM9 promotes the recruitment of MEI4 and IHO1, two proteins essential for DSB formation.
During the lengthy meiotic prophase, all autosomal chromosomes synapse, by forming a special protein structure called the synaptonemal complex, which connects the chromosomal axes. In contrast, the X and Y chromosome synapse only in the short homologous pseudoautosomal regions, and form the so-called XY body. 1 In this specialized chromatin ...
27 Μαΐ 2020 · Early pachynema was defined as complete autosomal synapsis, whereas the X and Y chromosomes could display various configuration: i) unsynapsed, with thickened PAR axes; ii) engaged in PAR...
5 Ιαν 2023 · DNA is condensed on chromosome axes where cohesin complexes and axis core proteins localize and spread as loops from axes. RAD21L and SYCP3 are shown as a representative of meiotic cohesin and axis core protein, respectively (B) Schematic representation of the mouse synaptonemal complex.
23 Μαρ 2006 · Introduction. During meiosis, chromosomes remain in an organized, individualized state for an extended period of time. This same period includes recombination at the DNA level, which has the unique feature that many of its steps occur within biochemical complexes that are physically associated with underlying chromosome structural axes.
1 Ιαν 2023 · In this review, we discuss the changes in chromatin conformation taking place between somatic and meiotic cells, with a special focus on the establishment of a proteinaceous structure, called the chromosome axis, at the beginning of meiosis.
10 Σεπ 2019 · While the components of the mammalian chromosome axis/LE-including meiosis-specific cohesin complexes, the axial element proteins SYCP3 and SYCP2, and the HORMA domain proteins HORMAD1 and HORMAD2-are known, the molecular organization of these components within the axis is poorly understood.
