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3 Δεκ 2019 · Food is well known to affect drug absorption by delaying gastric emptying time, altering gastrointestinal pH, stimulating bile flow, increasing splanchnic blood flow, or physically interacting with drugs [1–3].
27 Δεκ 2021 · Of the 3 BCS Class 1 drugs, all are weak bases, which were unaffected by food or gastric pH elevation. Of the 4 BCS Class 3 drugs, 3 had no FE (osimertinib, azacitidine, and baricitinib), while only betrixaban had a FE with a nearly 50% reduction in exposure with a high-fat meal.
Food-drug interactions can result in 2 main clinical effects: the decreased bioavailability of a drug, which predisposes to treatment failure, or an increased bioavailability, which increases the risk of adverse events and may even precipitate toxicities .
25 Μαρ 2023 · For BCS 1 and 3 drugs, clinically significant food effects are somewhat less frequently encountered, and due to high drug solubility, may be related to the impact of the fed state environment on aspects beyond the dissolution of the drug product.
THE WIDESPREAD USE OF PATENT MEDICINES ALONG with the broad variability in nutrition status, dietary habits, food composition, and dietary supplement use, set the stage for an infinite number of potential drug−nutrient interactions (DNIs).
Food-drug interactions may reduce the bioavailability of drugs taken after meals (negative food effects). However, enteric-coated tablets that start to disintegrate when they reach the middle-to-lower region of the small intestine could reduce negative food effects.
15 Ιουν 2019 · In this review of the UNGAP Working group “Food-Drug Interface”, the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.
